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Psoralen MOP Maleimide
Psoralens and their derivatives (such as 8-MOP and 4,5’8-TMP) are well known to have unique crosslinking features to DNA. However, psoralen monomers do not have sequence-specific crosslinking ability with a target DNA. Nakao et al found that 5-MOP more effectively crosslinks DNA compared to the well-known 8-MOP (https://doi.org/10.1002/cbic.202200789). Psoralen MOP Maleimide is a thiol-reactive 5-MOP derivative. It is an excellent building block for preparing MOP-labeled oligos from the readily available thiol-modified oligos. The 5-MOP-conjugated oligonucleotides can be used for sequence-specific crosslinking with a target DNA, thus enabling the application of psoralen-conjugated molecules in gene transcription inhibition, gene knockout, and other genomic applications. Psoralen MOP Maleimide may also be used for preparing site-specific DNA/RNA probes via the conjugations with thiol-containing biomolecules such as antibodies.
References
View all 50 references: Citation Explorer
The Use of Psoralen Photobinding to Study Transcription-Induced Supercoiling.
Authors: Kouzine, Fedor and Baranello, Laura and Levens, David
Journal: Methods in molecular biology (Clifton, N.J.) (2018): 95-108
Authors: Kouzine, Fedor and Baranello, Laura and Levens, David
Journal: Methods in molecular biology (Clifton, N.J.) (2018): 95-108
Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence.
Authors: Hovest, Miriam G and Krieg, Thomas and Herrmann, Gernot
Journal: Experimental dermatology (2011): 883-9
Authors: Hovest, Miriam G and Krieg, Thomas and Herrmann, Gernot
Journal: Experimental dermatology (2011): 883-9
Tanning caused by psoralen-photochemotherpy in Indian skin.
Authors: Gupta, Somesh and Ajith, C
Journal: Indian journal of dermatology, venereology and leprology (2009): 76-7
Authors: Gupta, Somesh and Ajith, C
Journal: Indian journal of dermatology, venereology and leprology (2009): 76-7
Senescence of human fibroblasts after psoralen photoactivation is mediated by ATR kinase and persistent DNA damage foci at telomeres.
Authors: Hovest, Miriam Grosse and Brüggenolte, Nicole and Hosseini, Kijawasch Shah and Krieg, Thomas and Herrmann, Gernot
Journal: Molecular biology of the cell (2006): 1758-67
Authors: Hovest, Miriam Grosse and Brüggenolte, Nicole and Hosseini, Kijawasch Shah and Krieg, Thomas and Herrmann, Gernot
Journal: Molecular biology of the cell (2006): 1758-67
The contribution of medical physics to the development of psoralen photochemotherapy (PUVA) in the UK: a personal reminiscence.
Authors: Diffey, Brian
Journal: Physics in medicine and biology (2006): R229-44
Authors: Diffey, Brian
Journal: Physics in medicine and biology (2006): R229-44
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