PerCP/Cy5.5 Anti-human CD27 Antibody *O323*

O323 is an anti-human monoclonal antibody that is specific for the CD27 antigen. CD27 (also known as S152, TNFRSF7 or T14) is a 50 - 55 kD single-pass type I membrane protein that is found on the surface of cells such as T cells, B cells and NK cells. In some organisms, CD27 promotes B cell differentiation, inhibits apoptotic process and positively regulates NIK/NF-kappaB signaling. Additionally, it is a member of vital cellular pathways, for instance, the extrinsic apoptotic signaling pathway, cell surface receptor signaling pathway and tumor necrosis factor-mediated signaling pathway. From a research standpoint, it is of biological interest due to its association with key macromolecules/ligands such as CD70. CD27 is a moderately popular antibody target, with over 11000 publications in the last decade. CD27 is vital to costimulatory molecules research, typically serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to PerCP/Cy5.5 (ex/em = 489/679 nm). It is compatible with the 488 nm laser and 695/40 nm bandpass filter (for example, as in the BD FACSCanto™).

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