PE/Texas Red® Anti-human CD6 Antibody *HI210*

HI210 is an anti-human monoclonal antibody that is specific for the CD6 antigen. CD6 (sometimes called TP120, OX52 or T12) is a 100 - 130 kD single-pass type I membrane protein that is located on the surface of cells such as T cells and B cells. In some organisms, CD6 acts to positively regulate T cell proliferation and enhances cytokine production involved in inflammatory response. Additionally, it acts in critical cellular pathways, in particular, the lipopolysaccharide-mediated signaling pathway. From a research standpoint, it is of biological interest due to its association with vital macromolecules/ligands such as CD166 (ALCAM), gp40 and gp90. CD6 is a fairly uncommon antibody target, with a little more than 1200 publications in the last decade. Even still, CD6 is commonly used in flow cytometry applications as a phenotypic marker for differentiation of cell types, specifically in the study of immunology. This antibody was purified through affinity chromatography and conjugated to PE/Texas Red® (ex/em = 567/615 nm). It is compatible with the 561 nm laser and 610/20 nm bandpass filter (for example, as in the BD FACSAria™ III).

Page updated on November 12, 2024