PE/Cy7 Anti-human CD2 Antibody *RPA-2.10*

RPA-2.10 is an anti-human monoclonal antibody that is specific for the CD2 antigen. CD2 (sometimes referred to as T11, Rosette receptor, Erythrocyte receptor or LFA-2) is a 45 kD single-pass type I membrane protein that is located on the surface of cells such as T cells, B cells and NK cells. In certain organisms, CD2 positively regulates interleukin-8 secretion, enhances myeloid dendritic cell activation and is an enhancer of interferon-gamma secretion. Also, it has been thought to be involved with important biological processes like cell-cell adhesion, specifically heterotypic cell-cell adhesion. CD2 is involved with key cellular pathways, in particular, the cell surface receptor signaling pathway. From a research standpoint, it is of biological interest due to its association with key macromolecules/ligands like CD48, LFA-3 and CD58. CD2 is a moderately popular antibody target, with over 16000 publications in the last decade. CD2 is commonly used in flow cytometry applications as a phenotypic marker for differentiation of cell types, specifically in the study of costimulatory molecules and immunology. This antibody was purified through affinity chromatography and conjugated to PE/Cy7 (ex/em = 566/778 nm). It is compatible with the 561 nm laser and 780/60 nm bandpass filter (for example, as in the BD LSRFortessa™ X-20).

Page updated on December 17, 2024