PacOrange Anti-human/ non-human primates CD89 Antibody *A59*

The A59 monoclonal antibody binds with human/ non-human primates CD89, a 55 - 100 kD single-pass type I membrane protein often expressed on the surface of macrophages, eosinophils and neutrophils. CD89 acts in critical cellular pathways, in particular, the Fc receptor signaling pathway. Furthermore, in certain organisms, it upregulates neutrophil apoptotic process and is a promoter of oxidative stress-induced cell death. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands such as IgA2 and IgA1. CD89 is a relatively rare antibody target, with fewer than 500 publications in the last decade. Even still, CD89 is essential for immunology research, often serving as a phenotypic marker for differentiating cell types in flow cytometric applications. This antibody was purified through affinity chromatography and conjugated to PacOrange (ex/em = 400/551 nm). It is compatible with the 405 nm laser and 528/45 nm bandpass filter (for example, as in the BD FACSMelody™).

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