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FITC–dextran conjugate (average MW = ~70K)
FITC-labeled dextran is used in cardiovascular, microcirculation, perfusion, cell monolayer and cell membrane permeability research as fluorescent flux tracer compound that supports the measurement of processes such as blood flow, membrane damage, vascular drainage and renal elimination. It is also used in microcirculation and cell permeability research utilizing microfluorimetry, and possible in perfusion studies in animals. FITC-dextran has also been used to study plant cell wall porosity and capillary permeability. Plasma proteins have been shown not to bind to FITC-dextran. FITC-dextran of ~70 kDa may be used as a model compound for development of methods to deliver molecules into protoplasts and to study drug release from structures such as hydrogels and liposomes. It may be used in microvascular and cell monolayer permeability studies.
Spectrum
Product family
| Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) | Quantum yield | Correction Factor (280 nm) |
| FITC–dextran conjugate (average MW = ~20K) | 491 | 516 | 73000 | 0.92 | 0.35 |
| FITC–dextran conjugate (average MW = ~150K) | 491 | 516 | 73000 | 0.92 | 0.35 |
| TRITC–dextran conjugate (average MW = ~70K) | 544 | 570 | 100000 | - | 0.34 |
Citations
View all 45 citations: Citation Explorer
Monitoring the Cascade of Monocyte-Derived Macrophages to Influenza Virus Infection in Human Alveolus Chips
Authors: Wang, Chenguang and Liu, Shujun and Li, Chuyu and Wang, Zhongjie and Ming, Ruiqi and Huang, Lili
Journal: ACS Applied Materials \& Interfaces (2024)
Authors: Wang, Chenguang and Liu, Shujun and Li, Chuyu and Wang, Zhongjie and Ming, Ruiqi and Huang, Lili
Journal: ACS Applied Materials \& Interfaces (2024)
Vitexin Suppresses High-Glucose-upregulated Adhesion Molecule Expression in Endothelial Cells through Inhibiting NF-$\kappa$B Signaling Pathway
Authors: Chen, Pie-Che and Chang, Yun-Ching and Tsai, Kun-Ling and Shen, Cheng Huang and Lee, Shin-Da
Journal: ACS Omega (2024)
Authors: Chen, Pie-Che and Chang, Yun-Ching and Tsai, Kun-Ling and Shen, Cheng Huang and Lee, Shin-Da
Journal: ACS Omega (2024)
Lymphatic Reconnection and Restoration of Lymphatic Flow by Nonvascularized Lymph Node Transplantation: Real-Time Fluorescence Imaging Using Indocyanine Green and Fluorescein Isothiocyanate-Dextran
Authors: Maeda, T., Yamamoto, Y., Iwasaki, D., Hayashi, T., Funayama, E., Oyama, A., Murao, N., Furukawa, H.
Journal: Lymphat Res Biol (2018): 165-173
Authors: Maeda, T., Yamamoto, Y., Iwasaki, D., Hayashi, T., Funayama, E., Oyama, A., Murao, N., Furukawa, H.
Journal: Lymphat Res Biol (2018): 165-173
Optimizing Fluorescein Isothiocyanate Dextran Measurement As a Biomarker in a 24-h Feed Restriction Model to Induce Gut Permeability in Broiler Chickens
Authors: Baxter, M. F. A., Merino-Guzman, R., Latorre, J. D., Mahaffey, B. D., Yang, Y., Teague, K. D., Graham, L. E., Wolfenden, A. D., Hern and ez-Velasco, X., Bielke, L. R., Hargis, B. M., Tellez, G.
Journal: Front Vet Sci (2017): 56
Authors: Baxter, M. F. A., Merino-Guzman, R., Latorre, J. D., Mahaffey, B. D., Yang, Y., Teague, K. D., Graham, L. E., Wolfenden, A. D., Hern and ez-Velasco, X., Bielke, L. R., Hargis, B. M., Tellez, G.
Journal: Front Vet Sci (2017): 56
Fluorescein Isothiocyanate (FITC)-Dextran Extravasation as a Measure of Blood-Brain Barrier Permeability
Authors: Natarajan, R., Northrop, N., Yamamoto, B.
Journal: Curr Protoc Neurosci (2017): 9 58 1-9 58 15
Authors: Natarajan, R., Northrop, N., Yamamoto, B.
Journal: Curr Protoc Neurosci (2017): 9 58 1-9 58 15
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