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DiA [4-(4-(Dihexadecylamino)styryl)-N-methylpyridinium iodide]

DiA is a lipophilic fluorescent stain for labeling membranes and other hydrophobic structures. It has the environment-sensitive fluorescence that is greatly enhanced when incorporated into membranes or bound to lipophilic biomolecules such as proteins although it is weakly fluorescent in water. Once applied to cells, this dye diffuses laterally within the cellular plasma membranes, resulting in even staining of the entire cell at its optimal concentrations.

Spectrum

Citations

View all 43 citations: Citation Explorer
Overexpression of c-Met in bone marrow mesenchymal stem cells improves their effectiveness in homing and repair of acute liver failure
Authors: Wang, Kun and Li, Yuwen and Zhu, Tiantian and Zhang, Yongting and Li, Wenting and Lin, Wenyu and Li, Jun and Zhu, Chuanlong
Journal: Stem Cell Research & Therapy (2017): 162
The accelerated blood clearance phenomenon of PEGylated nanoemulsion upon cross administration with nanoemulsions modified with polyglycerin
Authors: Su, Yuqing and Wang, Lirong and Liang, Kaifan and Liu, Mengyang and Liu, Xinrong and Song, Yanzhi and Deng, Yihui
Journal: Asian Journal of Pharmaceutical Sciences (2017)
In vivo imaging system for explants analysis–A new approach for assessment of cell transplantation effects in large animal models
Authors: Zarychta-Wisniewska, Weronika and Burdzinska, Anna and Zagozdzon, Radoslaw and Dybowski, Bartosz and Butrym, Marta and Gajewski, Zdzislaw and Paczek, Leszek
Journal: PloS one (2017): e0184588
On-Demand Drug Releasing from Dual Targeting Small Nanoparticles Triggered by High Intensity Focused Ultrasound Enhanced Glioblastoma Targeting Therapy
Authors: Luo, Zimiao and Jin, Kai and Pang, Qiang and shen, shun and Yan, Zhiqiang and Jiang, Ting and Zhu, Xiaoyan and Yu, Lei and Pang, Zhiqing and Jiang, Xinguo
Journal: ACS Applied Materials & Interfaces (2017)
Cyclic RGD peptide-modified liposomal drug delivery system for targeted oral apatinib administration: enhanced cellular uptake and improved therapeutic effects
Authors: Song, Zhiwang and Lin, Yun and Xia Zhang, Chan Feng and Lu, Yonglin and Gao, Yong and Dong, Chunyan
Journal: International Journal of Nanomedicine (2017): 1941

References

View all 92 references: Citation Explorer
Confocal laser scanning microscopy using dialkylcarbocyanine dyes for cell tracing in hard and soft biomaterials
Authors: Heinrich L, Freyria AM, Melin M, Tourneur Y, Maksoud R, Bernengo JC, Hartmann DJ.
Journal: J Biomed Mater Res B Appl Biomater. (2006)
In vivo imaging and counting of rat retinal ganglion cells using a scanning laser ophthalmoscope
Authors: Higashide T, Kawaguchi I, Ohkubo S, Takeda H, Sugiyama K.
Journal: Invest Ophthalmol Vis Sci (2006): 2943
Functional neuroanatomy of the rhinophore of Aplysia punctata
Authors: Wertz A, Rossler W, Obermayer M, Bickmeyer U.
Journal: Front Zool (2006): 6
Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing
Authors: Kalchenko V, Shivtiel S, Malina V, Lapid K, Haramati S, Lapidot T, Brill A, Harmelin A.
Journal: J Biomed Opt (2006): 50507
Nox2, Ca2+, and protein kinase C play a role in angiotensin II-induced free radical production in nucleus tractus solitarius
Authors: Wang G, Anrather J, Glass MJ, Tarsitano MJ, Zhou P, Frys KA, Pickel VM, Iadecola C.
Journal: Hypertension (2006): 482
Page updated on December 17, 2024

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Catalog Number22030
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Physical properties

Molecular weight

787.04

Solvent

DMSO

Spectral properties

Excitation (nm)

492

Emission (nm)

613

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
UNSPSC12352200

CAS

114041-00-8