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BTA-2 [2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole]
BTA-2 is an uncharged derivative of Thioflavin-T that exhibits high affinity for amyloid deposits [Ki = 143 nM for Ab(1-40)] and can cross the blood brain barrier. It displays up to 6-fold higher affinity than ThT and stains both plaques and neurofibrillary tangles in post mortem Alzheimer's disease brain.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of BTA-2 [2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 372.606 µL | 1.863 mL | 3.726 mL | 18.63 mL | 37.261 mL |
| 5 mM | 74.521 µL | 372.606 µL | 745.212 µL | 3.726 mL | 7.452 mL |
| 10 mM | 37.261 µL | 186.303 µL | 372.606 µL | 1.863 mL | 3.726 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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Spectrum
Product family
| Name | Excitation (nm) | Emission (nm) |
| 2-Aminoacridone *CAS 27918-14-5* | 429 | 529 |
| BTA-1 [2-(4'-(methylamino)phenyl)benzothiazole] | 349 | 421 |
| 2-NBDG [2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose] *CAS#: 186689-07-6* | 467 | 538 |
References
View all 7 references: Citation Explorer
Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114)
Authors: LeVine H, 3rd.
Journal: Biochemistry (2005): 15937
Authors: LeVine H, 3rd.
Journal: Biochemistry (2005): 15937
Multiple ligand binding sites on A beta(1-40) fibrils
Authors: LeVine H, 3rd.
Journal: Amyloid (2005): 5
Authors: LeVine H, 3rd.
Journal: Amyloid (2005): 5
Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET
Authors: Solbach C, Uebele M, Reischl G, Machulla HJ.
Journal: Appl Radiat Isot (2005): 591
Authors: Solbach C, Uebele M, Reischl G, Machulla HJ.
Journal: Appl Radiat Isot (2005): 591
Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies
Authors: Ishikawa K, Doh-ura K, Kudo Y, Nishida N, Murakami-Kubo I, Ando Y, Sawada T, Iwaki T.
Journal: J Gen Virol (2004): 1785
Authors: Ishikawa K, Doh-ura K, Kudo Y, Nishida N, Murakami-Kubo I, Ando Y, Sawada T, Iwaki T.
Journal: J Gen Virol (2004): 1785
Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease
Authors: Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.
Journal: J Mol Neurosci (2004): 55
Authors: Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.
Journal: J Mol Neurosci (2004): 55
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