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BTA-1 [2-(4'-(methylamino)phenyl)benzothiazole]
BTA-1 is a fluorescent Thioflavin-T derivative that exhibits high affinity for amyloid deposits (Ki = 11 nM for Ab 40). It crosses the blood brain barrier and displays up to 50-fold higher affinity than Thioflavin-T, and used for selectively staining cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice.
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Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of BTA-1 [2-(4'-(methylamino)phenyl)benzothiazole] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 416.112 µL | 2.081 mL | 4.161 mL | 20.806 mL | 41.611 mL |
| 5 mM | 83.222 µL | 416.112 µL | 832.224 µL | 4.161 mL | 8.322 mL |
| 10 mM | 41.611 µL | 208.056 µL | 416.112 µL | 2.081 mL | 4.161 mL |
Molarity calculator
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| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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Spectrum
Product family
| Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) |
| Oxazine 1 *CAS 24796-94-9* | 648 | 668 | 123000 |
| DiTO™-1 [equivalent to TOTO®-1] *5 mM DMSO Solution* *CAS 143413-84-7* | 514 | 531 | 1170001 |
| DiYO™-1 [equivalent to YOYO®-1] *5 mM DMSO Solution* | 491 | 508 | 989001 |
| JC-1 [5,5,6,6-Tetrachloro-1,1,3,3-tetraethylbenzimidazolylcarbocyanine iodide] *CAS#: 3520-43-2* | 515 | 530 | 1950001 |
| BTA-2 [2-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole] | 355 | 426 | - |
| DiYO™-1 [equivalent to YOYO®-1] | 491 | 508 | 989001 |
| DiPO™-1 [equivalent to POPO®-1] *1 mM DMSO Solution* | 433 | 457 | 920001 |
| EthD-1 [Ethidium Homodimer-1] | 528 | 617 | - |
References
View all 7 references: Citation Explorer
Mechanism of A beta(1-40) fibril-induced fluorescence of (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene (K114)
Authors: LeVine H, 3rd.
Journal: Biochemistry (2005): 15937
Authors: LeVine H, 3rd.
Journal: Biochemistry (2005): 15937
Multiple ligand binding sites on A beta(1-40) fibrils
Authors: LeVine H, 3rd.
Journal: Amyloid (2005): 5
Authors: LeVine H, 3rd.
Journal: Amyloid (2005): 5
Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET
Authors: Solbach C, Uebele M, Reischl G, Machulla HJ.
Journal: Appl Radiat Isot (2005): 591
Authors: Solbach C, Uebele M, Reischl G, Machulla HJ.
Journal: Appl Radiat Isot (2005): 591
Amyloid imaging probes are useful for detection of prion plaques and treatment of transmissible spongiform encephalopathies
Authors: Ishikawa K, Doh-ura K, Kudo Y, Nishida N, Murakami-Kubo I, Ando Y, Sawada T, Iwaki T.
Journal: J Gen Virol (2004): 1785
Authors: Ishikawa K, Doh-ura K, Kudo Y, Nishida N, Murakami-Kubo I, Ando Y, Sawada T, Iwaki T.
Journal: J Gen Virol (2004): 1785
Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease
Authors: Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.
Journal: J Mol Neurosci (2004): 55
Authors: Wang Y, Klunk WE, Debnath ML, Huang GF, Holt DP, Shao L, Mathis CA.
Journal: J Mol Neurosci (2004): 55
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