Anti-Cystatin-C protein antibody *Mouse anti-human, monoclonal IgG1*
Cystatin C (CYSC) is a non-glycosylated, low molecular weight protein synthesized by most nucleated cells. It is present in all tissues and body fluids acting as a potent inhibitor of lysosomal proteinases and as an extracellular inhibitor of cysteine proteases. CYSC is primarily used a biomarker of renal function, but also has associations with obesity, insulin resistance, hypertension, and cardiovascular mortality. Under normal conditions, CYSC in serum is 0.47 " 1.09 mg/L. When renal function is impaired, CYCS concentration in blood will change with glomerular filtration rate (GFR). During renal failure, GFR decreases while CYSC blood concentration increases more than 10-fold. Anti-CYSC monoclonal antibodies are highly sensitive for the detection of human CYSC proteins. They can be used for a broad range of CYSC immunoassays such as latex enhanced turbidimetric immunoassays (LETIA).
![Clinical comparison of AAT Bioquest’s CYSC reagent and commercial kit.](/_next/image?url=https%3A%2F%2Fimages.aatbio.com%2Fproducts%2Ffigures-and-data%2Fanti-cystatin-c-protein-antibody-mouse-anti-human-monoclonal-igg1%2Ffigure-for-anti-cystatin-c-protein-antibody-mouse-anti-human-monoclonal-igg1_NeZMt.jpg&w=640&q=75)
![Clinical comparison of AAT Bioquest’s CYSC reagent and commercial kit.](/_next/image?url=https%3A%2F%2Fimages.aatbio.com%2Fproducts%2Ffigures-and-data%2Fanti-cystatin-c-protein-antibody-mouse-anti-human-monoclonal-igg1%2Ffigure-for-anti-cystatin-c-protein-antibody-mouse-anti-human-monoclonal-igg1_NeZMt.jpg&w=640&q=75)
![Clinical comparison of AAT Bioquest’s CYSC reagent and commercial kit.](/_next/image?url=https%3A%2F%2Fimages.aatbio.com%2Fproducts%2Ffigures-and-data%2Fanti-cystatin-c-protein-antibody-mouse-anti-human-monoclonal-igg1%2Ffigure-for-anti-cystatin-c-protein-antibody-mouse-anti-human-monoclonal-igg1_NeZMt.jpg&w=128&q=25)
![Calibration curve for CYSC LETIA assay: human CYSC were reacted with anti-human CYSC antibody-coated latex, resulting in agglutination and increase in turbidity. Turbidity changes were monitored using a spectrometer to quantitatively measure the CYSC concentration in the sample.](/_next/image?url=https%3A%2F%2Fimages.aatbio.com%2Fproducts%2Ffigures-and-data%2Fanti-cystatin-c-protein-antibody-mouse-anti-human-monoclonal-igg1%2Ffigure-for-anti-cystatin-c-protein-antibody-mouse-anti-human-monoclonal-igg1_CCRth.jpg&w=128&q=25)
![Effect of repeated freeze-thaw on CYSC antibodies: anti-CYSC monoclonal antibodies (Cat# V100030) were subjected to subsequent freeze-thaw cycles from -20°C to 20°C. Anti-CYSC monoclonal antibodies were stable after five repeated freeze-thaw cycles.](/_next/image?url=https%3A%2F%2Fimages.aatbio.com%2Fproducts%2Ffigures-and-data%2Fanti-cystatin-c-protein-antibody-mouse-anti-human-monoclonal-igg1%2Ffigure-for-anti-cystatin-c-protein-antibody-mouse-anti-human-monoclonal-igg1_OIkDl.jpg&w=128&q=25)
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of Anti-Cystatin-C protein antibody *Mouse anti-human, monoclonal IgG1* with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.