Anti-Cystatin-C protein antibody *Mouse anti-human, monoclonal IgG1*

Cystatin C (CYSC) is a non-glycosylated, low molecular weight protein synthesized by most nucleated cells. It is present in all tissues and body fluids acting as a potent inhibitor of lysosomal proteinases and as an extracellular inhibitor of cysteine proteases. CYSC is primarily used a biomarker of renal function, but also has associations with obesity, insulin resistance, hypertension, and cardiovascular mortality. Under normal conditions, CYSC in serum is 0.47 " 1.09 mg/L. When renal function is impaired, CYCS concentration in blood will change with glomerular filtration rate (GFR). During renal failure, GFR decreases while CYSC blood concentration increases more than 10-fold. Anti-CYSC monoclonal antibodies are highly sensitive for the detection of human CYSC proteins. They can be used for a broad range of CYSC immunoassays such as latex enhanced turbidimetric immunoassays (LETIA).

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