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AAT Bioquest

Anti-17-alpha-hydroxyprogesterone antibody *Mouse anti-human, monoclonal IgG1*

17 alpha-hydroxyprogesterone (17 α-OHP) is a steroid hormone synthesized from progesterone. It acts as an agonist of the progesterone receptor and is a precursor in the biosynthesis of many other steroids such as glucocorticoids, androgens and estrogens. In clinical biology, measuring 17 α-OHP levels in the blood are useful in the detection and evaluation of congenital adrenal hyperplasia (CAH). Patients with CAH express insufficient amounts of the enzyme 21-hydroxylase, which is necessary for the conversion of 17 α-OHP into cortisol. As a result, 17 α-OHP levels in the blood build up. Anti-17 α-OHP monoclonal antibodies are highly sensitive for the detection of 17 α-OHP. They can be used for a broad range of immunoassays such as competitive chemiluminescence immunoassays (CLIA) and ELISA.

Conjugation

We provide custom conjugation services for this antibody (eg. labeling of Anti-17-alpha-hydroxyprogesterone antibody *Mouse anti-human, monoclonal IgG1* with HRP). A list of available labels can be found in the table below:

AFAF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750
ProteinsHRP, Alkaline Phosphatase, Streptavidin
TandemsAPC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5
Small MoleculesBiotin
Traditional DyesFITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5
iFluor350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7
mFluorUV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780

For additional information about custom conjugations, please consult our services page here.
Page updated on October 31, 2024

Ordering information

Price
Unit size
50 ug
1 mg
Catalog Number
Quantity
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Additional ordering information

Telephone1-800-990-8053
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Emailsales@aatbio.com
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Antibody properties

Other names
Hostmouse
Reactivityhuman
ApplicationCLIA

Storage, safety and handling

Intended useResearch Use Only (RUO)
Clinical comparison of AAT Bioquest’s 17 α -OHP immunoassay and a competitor’s immunoassay: 27 clinical blood samples were tested using 17 α -OHP monoclonal antibodies from AAT Bioquest on a CLIA platform. Data from this study were compared to that of a competitor’s diagnostic kit.
Clinical comparison of AAT Bioquest’s 17 α -OHP immunoassay and a competitor’s immunoassay: 27 clinical blood samples were tested using 17 α -OHP monoclonal antibodies from AAT Bioquest on a CLIA platform. Data from this study were compared to that of a competitor’s diagnostic kit.
Clinical comparison of AAT Bioquest’s 17 α -OHP immunoassay and a competitor’s immunoassay: 27 clinical blood samples were tested using 17 α -OHP monoclonal antibodies from AAT Bioquest on a CLIA platform. Data from this study were compared to that of a competitor’s diagnostic kit.
Competition curve for 17 α -OHP in competitive chemiluminescence immunoassay (CLIA): monoclonal antibodies and 17α-OHP standards were added to a microplate pre-coated with 17 α-OHP conjugates. Secondary detection antibodies were labeled with horseradish peroxidase (HRP). Quantity of HRP combination was inversely proportional to the amount of standard.