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Actinomycin D
Actinomycin is a polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. It binds to DNA duplexes, thereby interfering with the action of enzymes engaged in replication and transcription. Actinomycin D is one of the old chemotherapy drugs which have been used in therapy for many years.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Actinomycin D to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 79.655 µL | 398.273 µL | 796.546 µL | 3.983 mL | 7.965 mL |
| 5 mM | 15.931 µL | 79.655 µL | 159.309 µL | 796.546 µL | 1.593 mL |
| 10 mM | 7.965 µL | 39.827 µL | 79.655 µL | 398.273 µL | 796.546 µL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
| / | = | x | = |
Product family
| Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) |
| D-Aminoluciferin | 362 | 499 | 18000 |
Citations
View all 14 citations: Citation Explorer
Hypoxia-driven M2-polarized macrophages facilitate the epithelial-mesenchymal transition of glioblastoma via extracellular vesicles
Authors: Liu, Liang and Wang, Ran and Alifu, Aogesi and Xiao, Yong and Liu, Yong and Qian, Chunfa and Zhao, Mengjie and Tang, Xianglong and Xie, Yandong and Shi, Yan and others,
Journal: Theranostics (2024): 6392
Authors: Liu, Liang and Wang, Ran and Alifu, Aogesi and Xiao, Yong and Liu, Yong and Qian, Chunfa and Zhao, Mengjie and Tang, Xianglong and Xie, Yandong and Shi, Yan and others,
Journal: Theranostics (2024): 6392
METTL14 inhibits the malignant processes of gastric cancer cells by promoting N6-methyladenosine (m6A) methylation of TAF10
Authors: Zhao, Xin and Lu, Jingfen and Wu, Weimin and Li, Jiahui
Journal: Heliyon (2024)
Authors: Zhao, Xin and Lu, Jingfen and Wu, Weimin and Li, Jiahui
Journal: Heliyon (2024)
Circ\_0044235 regulates the development of osteoarthritis by the modulation of miR-375/PIK3R3 axis
Authors: Qian, Wenjie and Mei, Kai and Zhu, Lei and Chu, Ying and Lv, Jinpeng and Yun, Changjun
Journal: Journal of Orthopaedic Surgery and Research (2024): 241
Authors: Qian, Wenjie and Mei, Kai and Zhu, Lei and Chu, Ying and Lv, Jinpeng and Yun, Changjun
Journal: Journal of Orthopaedic Surgery and Research (2024): 241
HBV DNA polymerase upregulates the transcription of PD-L1 and suppresses T cell activity in hepatocellular carcinoma
Authors: Jia, Yan and Zhao, Jianing and Wang, Chunqing and Meng, Jing and Zhao, Liqing and Yang, Hongwei and Zhao, Xiaoqing
Journal: Journal of Translational Medicine (2024): 1--17
Authors: Jia, Yan and Zhao, Jianing and Wang, Chunqing and Meng, Jing and Zhao, Liqing and Yang, Hongwei and Zhao, Xiaoqing
Journal: Journal of Translational Medicine (2024): 1--17
N6-methyladenosine-regulated ADIRF impairs lung adenocarcinoma metastasis and serves as a potential prognostic biomarker
Authors: Teng, Yin and Zhao, Xiaohan and Xi, Yang and Fu, Ninghua
Journal: Cancer Biology \& Therapy (2023): 2249173
Authors: Teng, Yin and Zhao, Xiaohan and Xi, Yang and Fu, Ninghua
Journal: Cancer Biology \& Therapy (2023): 2249173
References
View all 66 references: Citation Explorer
Fluorescent intercalator displacement analyses of DNA binding by the peptide-derived natural products netropsin, actinomycin, and bleomycin
Authors: Lewis MA, Long EC.
Journal: Bioorg Med Chem (2006): 3481
Authors: Lewis MA, Long EC.
Journal: Bioorg Med Chem (2006): 3481
Downregulation of inhibitor of apoptosis proteins in apoptotic human chondrocytes treated with tumor necrosis factor-alpha and actinomycin D
Authors: Yoshimura F, Kanno H, Uzuki M, Tajima K, Shimamura T, Sawai T.
Journal: Osteoarthritis Cartilage (2006): 435
Authors: Yoshimura F, Kanno H, Uzuki M, Tajima K, Shimamura T, Sawai T.
Journal: Osteoarthritis Cartilage (2006): 435
Anti-apoptotic effect of hepatocyte growth factor from actinomycin D in hepatocyte-derived HL7702 cells is associated with activation of PI3K/Akt signaling
Authors: Li W, Cai S, Cai L, Li X.
Journal: Toxicol Lett (2006): 142
Authors: Li W, Cai S, Cai L, Li X.
Journal: Toxicol Lett (2006): 142
Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway
Authors: Kim HS, Loughran PA, Kim PK, Billiar TR, Zuckerbraun BS.
Journal: Biochem Biophys Res Commun (2006): 1172
Authors: Kim HS, Loughran PA, Kim PK, Billiar TR, Zuckerbraun BS.
Journal: Biochem Biophys Res Commun (2006): 1172
Single-dose actinomycin D: Efficacy in the prophylaxis of postmolar gestational trophoblastic neoplasia in adolescents with high-risk hydatidiform mole
Authors: Uberti EM, Diestel MC, Guimaraes FE, De Napoli G, Schmid H.
Journal: Gynecol Oncol (2006): 325
Authors: Uberti EM, Diestel MC, Guimaraes FE, De Napoli G, Schmid H.
Journal: Gynecol Oncol (2006): 325
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