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2’,3’-cGAMP succinimidyl ester
2’,3’-cGAMP succinimidyl ester is an excellent reagent to covalently conjugate 2’,3’-cGAMP to biological targets, such as proteins, peptides, and nucleic acids. 2’,3’-cGAMP has gained significant attention in recent years due to its potential as a therapeutic target for diseases such as cancer and viral infections. It has been shown to activate the immune system and enhance the efficacy of immune checkpoint inhibitors, which are a type of cancer immunotherapy. 2’,3’-cGAMP (cyclic GMP-AMP) is a cyclic dinucleotide second messenger molecule that plays a critical role in the innate immune system. It is synthesized by the enzyme cGAS (cyclic GMP-AMP synthase) in response to cytosolic DNA that has been released from damaged or infected cells. Once synthesized, 2’,3’-cGAMP binds to the adaptor protein STING (stimulator of interferon genes) and triggers downstream signaling pathways that result in the production of type I interferons and other cytokines, leading to an immune response against the invading pathogen.
References
View all 50 references: Citation Explorer
Nuclear translocation of cGAS orchestrates VEGF-A-mediated angiogenesis.
Authors: Luo, Juanjuan and Lu, Chunjiao and Chen, Yang and Wu, Xuewei and Zhu, Chenchen and Cui, Wei and Yu, Shicang and Li, Ningning and Pan, Yihang and Zhao, Weijiang and Yang, Qingkai and Yang, Xiaojun
Journal: Cell reports (2023): 112328
Authors: Luo, Juanjuan and Lu, Chunjiao and Chen, Yang and Wu, Xuewei and Zhu, Chenchen and Cui, Wei and Yu, Shicang and Li, Ningning and Pan, Yihang and Zhao, Weijiang and Yang, Qingkai and Yang, Xiaojun
Journal: Cell reports (2023): 112328
The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus.
Authors: Kong, Lingli and Sui, Chao and Chen, Tian and Zhang, Lei and Zhao, Wei and Zheng, Yi and Liu, Bingyu and Cheng, Xiaochen and Gao, Chengjiang
Journal: Cell reports (2023): 112306
Authors: Kong, Lingli and Sui, Chao and Chen, Tian and Zhang, Lei and Zhao, Wei and Zheng, Yi and Liu, Bingyu and Cheng, Xiaochen and Gao, Chengjiang
Journal: Cell reports (2023): 112306
Atractylenolide III suppresses senescence-associated secretome via inhibiting cGAS/NF-κB pathway in hepatic stellate cells.
Authors: Wu, Hongyan and Wu, Lixia and Xiao, Linxia and Gu, Yaqin and Liu, Hongxia and Zhang, Lihu and Zhang, Mingguang and Qi, Liang
Journal: Clinical and experimental pharmacology & physiology (2023): 316-324
Authors: Wu, Hongyan and Wu, Lixia and Xiao, Linxia and Gu, Yaqin and Liu, Hongxia and Zhang, Lihu and Zhang, Mingguang and Qi, Liang
Journal: Clinical and experimental pharmacology & physiology (2023): 316-324
TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Authors: Wang, Jie and Qin, Xiao and Huang, Yulu and Zhang, Qunmei and Pei, Jinyong and Wang, Yi and Goren, Idan and Ma, Shujun and Song, Zhishan and Liu, Yanzi and Xing, Hongxia and Wang, Hui and Yang, Bo
Journal: Autophagy (2023): 1-19
Authors: Wang, Jie and Qin, Xiao and Huang, Yulu and Zhang, Qunmei and Pei, Jinyong and Wang, Yi and Goren, Idan and Ma, Shujun and Song, Zhishan and Liu, Yanzi and Xing, Hongxia and Wang, Hui and Yang, Bo
Journal: Autophagy (2023): 1-19
Broad-spectrum antiviral inhibitors targeting pandemic potential RNA viruses.
Authors: Garcia, Gustavo and Irudayam, Joseph Ignatius and Jeyachandran, Arjit Vijay and Dubey, Swati and Chang, Christina and Cario, Sebastian Castillo and Price, Nate and Arumugam, Sathya and Marquez, Angelica L and Shah, Aayushi and Fanaei, Amir and Chakravarty, Nikhil and Joshi, Shantanu and Sinha, Sanjeev and French, Samuel W and Parcells, Mark and Ramaiah, Arunachalam and Arumugaswami, Vaithilingaraja
Journal: bioRxiv : the preprint server for biology (2023)
Authors: Garcia, Gustavo and Irudayam, Joseph Ignatius and Jeyachandran, Arjit Vijay and Dubey, Swati and Chang, Christina and Cario, Sebastian Castillo and Price, Nate and Arumugam, Sathya and Marquez, Angelica L and Shah, Aayushi and Fanaei, Amir and Chakravarty, Nikhil and Joshi, Shantanu and Sinha, Sanjeev and French, Samuel W and Parcells, Mark and Ramaiah, Arunachalam and Arumugaswami, Vaithilingaraja
Journal: bioRxiv : the preprint server for biology (2023)
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