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2’,3’-cGAMP azide
2’,3’-cGAMP azide is an excellent reagent to conjugate 2’,3’-cGAMP to alkyne-modified biological targets, such as proteins, peptides, and nucleic acids. 2’,3’-cGAMP has gained significant attention in recent years due to its potential as a therapeutic target for diseases such as cancer and viral infections. It has been shown to activate the immune system and enhance the efficacy of immune checkpoint inhibitors, which are a type of cancer immunotherapy. 2’,3’-cGAMP (cyclic GMP-AMP) is a cyclic dinucleotide second messenger molecule that plays a critical role in the innate immune system. It is synthesized by the enzyme cGAS (cyclic GMP-AMP synthase) in response to cytosolic DNA that has been released from damaged or infected cells. Once synthesized, 2’,3’-cGAMP binds to the adaptor protein STING (stimulator of interferon genes) and triggers downstream signaling pathways that result in the production of type I interferons and other cytokines, leading to an immune response against the invading pathogen.
References
View all 44 references: Citation Explorer
Microcystin-LR-induced nuclear translocation of cGAS promotes mutagenesis in human hepatocytes by impeding homologous recombination repair.
Authors: Wang, Xiaofei and Zhu, Yuchen and Lu, Wenzun and Guo, Xiaoying and Chen, Liuzeng and Zhang, Ning and Chen, Shaopeng and Ge, Chunmei and Xu, Shengmin
Journal: Toxicology letters (2023): 94-104
Authors: Wang, Xiaofei and Zhu, Yuchen and Lu, Wenzun and Guo, Xiaoying and Chen, Liuzeng and Zhang, Ning and Chen, Shaopeng and Ge, Chunmei and Xu, Shengmin
Journal: Toxicology letters (2023): 94-104
Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy.
Authors: He, Qingbin and Zheng, Runxiao and Ma, Junchi and Zhao, Luyang and Shi, Yafang and Qiu, Jianfeng
Journal: Biomaterials research (2023): 29
Authors: He, Qingbin and Zheng, Runxiao and Ma, Junchi and Zhao, Luyang and Shi, Yafang and Qiu, Jianfeng
Journal: Biomaterials research (2023): 29
Spermidine enhances the efficacy of adjuvant in HBV vaccination in mice.
Authors: Ito, Daisuke and Ito, Hiroyasu and Ando, Tatsuya and Sakai, Yasuhiro and Ideta, Takayasu and Ishii, Ken J and Ishikawa, Tetsuya and Shimizu, Masahito
Journal: Hepatology communications (2023)
Authors: Ito, Daisuke and Ito, Hiroyasu and Ando, Tatsuya and Sakai, Yasuhiro and Ideta, Takayasu and Ishii, Ken J and Ishikawa, Tetsuya and Shimizu, Masahito
Journal: Hepatology communications (2023)
TRIM7/RNF90 promotes autophagy via regulation of ATG7 ubiquitination during L. monocytogenes infection.
Authors: Wang, Jie and Qin, Xiao and Huang, Yulu and Zhang, Qunmei and Pei, Jinyong and Wang, Yi and Goren, Idan and Ma, Shujun and Song, Zhishan and Liu, Yanzi and Xing, Hongxia and Wang, Hui and Yang, Bo
Journal: Autophagy (2023): 1-19
Authors: Wang, Jie and Qin, Xiao and Huang, Yulu and Zhang, Qunmei and Pei, Jinyong and Wang, Yi and Goren, Idan and Ma, Shujun and Song, Zhishan and Liu, Yanzi and Xing, Hongxia and Wang, Hui and Yang, Bo
Journal: Autophagy (2023): 1-19
Cell-Free DNA Promotes Inflammation in Patients With Oral Lichen Planus via the STING Pathway.
Authors: Deng, Jing and Pan, Weiyi and Ji, Ning and Liu, Na and Chen, Qian and Chen, Jinhuan and Sun, Yutong and Xie, Liang and Chen, Qianming
Journal: Frontiers in immunology (2022): 838109
Authors: Deng, Jing and Pan, Weiyi and Ji, Ning and Liu, Na and Chen, Qian and Chen, Jinhuan and Sun, Yutong and Xie, Liang and Chen, Qianming
Journal: Frontiers in immunology (2022): 838109
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