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2’,3’-cGAMP-iFluor 488 conjugate
iFluor® 488-labeled cGAMP provides an excellent fluorescent probe for developing fluorescence-based assays and tests for detecting cGAMP or monitoring its activity. iFluor® 488 conjugates are significantly brighter than fluorescein conjugates and are much more photostable. Additionally, the fluorescence of iFluor® 488 is not affected by pH (4-10). 2’,3’-cGAMP has gained significant attention in recent years due to its potential as a therapeutic target for diseases such as cancer and viral infections. It has been shown to activate the immune system and enhance the efficacy of immune checkpoint inhibitors, which are a type of cancer immunotherapy. 2’,3’-cGAMP (cyclic GMP-AMP) is a cyclic dinucleotide second messenger molecule that plays a critical role in the innate immune system. It is synthesized by the enzyme cGAS (cyclic GMP-AMP synthase) in response to cytosolic DNA that has been released from damaged or infected cells. Once synthesized, 2’,3’-cGAMP binds to the adaptor protein STING (stimulator of interferon genes) and triggers downstream signaling pathways that result in the production of type I interferons and other cytokines, leading to an immune response against the invading pathogen.
Spectrum
Product family
| Name | Excitation (nm) | Emission (nm) | Extinction coefficient (cm -1 M -1) | Quantum yield | Correction Factor (260 nm) | Correction Factor (280 nm) | Correction Factor (656 nm) |
| 2’,3’-cGAMP-iFluor 647 conjugate | 656 | 670 | 2500001 | 0.251 | 0.03 | 0.03 | 0.0793 |
References
View all 49 references: Citation Explorer
Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity.
Authors: Zhang, Conggang and Han, Jing and Hu, Shuiqing and Hu, Yawei and Xu, Yifang and Hou, Yanfei and Yang, Yinlong and Su, Huili and Zhang, Zhengyin and Liu, Peng and Sun, Xuxu
Journal: Cancer immunology research (2023)
Authors: Zhang, Conggang and Han, Jing and Hu, Shuiqing and Hu, Yawei and Xu, Yifang and Hou, Yanfei and Yang, Yinlong and Su, Huili and Zhang, Zhengyin and Liu, Peng and Sun, Xuxu
Journal: Cancer immunology research (2023)
Improving poxvirus-mediated antitumor immune responses by deleting viral cGAMP-specific nuclease.
Authors: Riederer, Stephanie and Del Canizo, Ana and Navas, Javier and Peter, Marlowe G and Link, Ellen K and Sutter, Gerd and Rojas, Juan J
Journal: Cancer gene therapy (2023)
Authors: Riederer, Stephanie and Del Canizo, Ana and Navas, Javier and Peter, Marlowe G and Link, Ellen K and Sutter, Gerd and Rojas, Juan J
Journal: Cancer gene therapy (2023)
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling.
Authors: Gentili, Matteo and Liu, Bingxu and Papanastasiou, Malvina and Dele-Oni, Deborah and Schwartz, Marc A and Carlson, Rebecca J and Al'Khafaji, Aziz M and Krug, Karsten and Brown, Adam and Doench, John G and Carr, Steven A and Hacohen, Nir
Journal: Nature communications (2023): 611
Authors: Gentili, Matteo and Liu, Bingxu and Papanastasiou, Malvina and Dele-Oni, Deborah and Schwartz, Marc A and Carlson, Rebecca J and Al'Khafaji, Aziz M and Krug, Karsten and Brown, Adam and Doench, John G and Carr, Steven A and Hacohen, Nir
Journal: Nature communications (2023): 611
Potent Therapeutic Strategies for COVID-19 with Single-Domain Antibody Immunoliposomes Neutralizing SARS-CoV-2 and Lip/cGAMP Enhancing Protective Immunity.
Authors: Zhou, Yajun and Lu, Xing and Wang, Xiaoqing and Ying, Tianlei and Tan, Xiangshi
Journal: International journal of molecular sciences (2023)
Authors: Zhou, Yajun and Lu, Xing and Wang, Xiaoqing and Ying, Tianlei and Tan, Xiangshi
Journal: International journal of molecular sciences (2023)
cGAMP-activated cGAS-STING signaling: its bacterial origins and evolutionary adaptation by metazoans.
Authors: Patel, Dinshaw J and Yu, You and Xie, Wei
Journal: Nature structural & molecular biology (2023): 245-260
Authors: Patel, Dinshaw J and Yu, You and Xie, Wei
Journal: Nature structural & molecular biology (2023): 245-260
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