What triggers necrosis?

Necrosis can be triggered by several external factors and conditions. One factor is physical trauma, such as injuries from accidents or blunt force. Necrosis can also be triggered by toxins and chemicals such as illicit drugs, industrial chemicals, and environmental pollutants. Infections may also trigger necrosis, such as those caused by viruses which induce strong inflammatory responses. High levels of ionizing radiation, such as during radiation therapy for cancer treatments may result in unspecific and widespread necrosis in exposed tissues. Hypoxia and ischemia are also common causes of necrosis, and they can occur due to health conditions like arterial blockages, embolism, or thrombosis.