What is the significance of mRNA purification?

It is essential to achieve both high yield and high purity of mRNA to ensure the quality of the sample. High-purity mRNA is more efficiently translated into protein by ribosomes. By removing excess components like short or double-stranded RNA and DNA, enzymes or NTPs through purification, researchers can enhance translation efficiency and achieve better results. In medicine, mRNA purification is essential for ensuring the effectiveness of mRNA therapies and vaccines, as it helps maintain the purity of the mRNA and enhances its ability to stimulate a robust immune response. Additionally, the effectiveness and safety of mRNA drugs depend on the purity of the mRNA.