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AAT Bioquest

What are the similarities between positive and negative selection of T cells?

Posted August 18, 2023


Answer

Both positive and negative selection of T-cells play key roles in mediating adaptive immune responses. Both selection processes are involved in the development and maturation of T-cells. 

Both selection processes take place in the thymus and both are equally important for helping the immune system function correctly. Presentation of self-antigens is a common occurrence in both positive and negative selection processes.

Additional resources

Positive and negative selection of T cells

CD4 (Leu3, T4)

iFluor® 488 Anti-human CD4 Antibody *OKT-4*