logo
AAT Bioquest

What are the similarities between IGA and IGG?

Posted July 25, 2024


Answer

IGA and IGG are types of antibodies produced in the body as a secondary immune response. Both are crucial components of the humoral immune system and play key roles in fighting against bacterial and viral pathogens.  

IGA and IGG are both synthesized by activated plasma cells in response to antigen or antigenic markers produced in pathogenic antigens. Both are highly specific and bind to a specific epitope of a pathogenic antigen.

IGA and IGG are both large glycoproteins made up of four polypeptide chains – 2 heavy chains and 2 light chains – composed in a Y shape. They contain specialized regions known as paratopes at which they bind to the specific epitope of a pathogenic antigen. 

Additional resources

IgA anti-tissue transglutaminase antibodies and IgG antibodies against deamidated gliadin peptides as predictors of celiac disease

Antibodies and Proteomics

iFluor® 488 goat anti-mouse IgG (H+L) *Cross Adsorbed*