What are the limitations of single-nucleotide polymorphism (SNP) technique?
Posted June 4, 2024
Answer
Limitations of Single Nucleotide Polymorphism (SNP) Technique:
- The biallelic nature of SNPs reduces their informativity per locus compared to STRs
- Array platforms that run multiple SNPs simultaneously typically demand larger amounts of DNA than is possible to obtain from a small or degraded sample
- Currently limited data on X-chromosome SNP usage in forensic analysis (despite studies suggesting potential applicability in population characterization and relationship testing)
Additional resources
Large-Scale Validation of Single Nucleotide Polymorphisms in Gene Regions