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AAT Bioquest

What are the functions of immunoglobulin A (IgA)?

Posted July 31, 2024


Answer

Functions of immunoglobulin A (IgA):

  • IgA prevents passage of foreign substances into the circulatory system. 
  • It protects mucous membranes with its ability to traverse the epithelial layer and enter into body secretion where it provides local immunity 
  • With its abundance in mucosal secretions such as tears and saliva, IgA serves as the primary defense mechanism against some local infections
  • IgA neutralizes viruses and prevent them from attaching on host surface in body secretion. 
  • Helps to activate the complement pathway when aggregated
  • Secretory IgA provides a vital line of defense against several bacteria and can also inhibit inflammatory effects of other immunoglobulins.
Additional resources

Biochemistry, Immunoglobulin A

Antibodies and Proteomics

Purified Mouse Anti-human IgA Antibody *AD3, monoclonal*