What are the differences between LD50 and ED50?
Posted March 26, 2024
Answer
Key differences between LD50 and ED50:
LD50:
- LD50 stands for Lethal Dose 50%.
- It indicates the median lethal dose of a substance or the lethal dose for 50% of the individuals tested and is a key measure of drug toxicity.
ED50:
- ED50 stands for Effective Dose 50%.
- It indicates the median effective dose of a substance or the dose required to achieve 50% of the desired response in 50% of the population. In this case, efficacy is defined as the maximum effect that a drug can cause at any given dose. The smaller the ED50, the more potent the drug.
Additional resources
Is the prediction of LD50 using cell cultures generally valid?