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What are the differences between Isoschizomers and Neoschizomers?
Posted April 4, 2024
Answer
Isoschizomers
- Isoschizomers are restriction enzymes that have the same recognition sequence and cleave the DNA at the same positions.
- They have the same specificities and their formation is interchangeable
- They generate the same types of ends
- Examples include: Hpall and MSPI, Agel and BshT1, Kpn1 and Acc651
Neoschizomers
- Neoschizomers are restriction enzymes that have the same recognition sequence but cleave DNA at different positions
- They have different specificities and their formation is rigid and not interchangeable
- They generate different types of ends
- Examples include: Maell and Tail, Smal and Xmal, Apal and Bsp120l
Additional resources
Two different isoschizomers of the type-II restriction endonuclease Taq I (T/CGA) within the same Thermus isolate: Tsp32 I, an enzyme with similar heat stability properties to the prototype enzyme Taq I, and Tsp32 II, a hyperthermostable isoschizomer of Taq I
EnzymesRestriction Enzymes Cut Sites Reference Table
Amplite® Fluorimetric Coenzyme A Quantitation Kit *Green Fluorescence*