What are the differences between inversion and translocation?
Posted February 3, 2024
Basis of differentiation |
Inversion |
Translocation |
Definition |
Is a type of chromosomal rearrangement in which a chromosome segment breaks off, flips 180 degrees, and reattaches to the chromosome at the same location |
Is a type of chromosomal rearrangement in which parts of non-homologous chromosomes are exchanged between each other |
Location of rejoining |
Occurs in the same location within the same chromosome |
The location of the DNA fragment changes between chromosomes |
Number of chromosomes involved |
Involves only one chromosome |
Involves two chromosomes |
Significance |
Changes the orientation of a segment of a chromosome |
Interchanges parts of chromosomes between non-homologous chromosomes |
Change in chromosome size |
Chromosome size remains the same |
Chromosome size changes |
Chromosomal imbalance |
Chromosome rearrangement is balanced as there is no extra or missing DNA |
May be balanced or unbalanced |
Types |
May be paracentric or pericentric |
May be reciprocal or Robertsonian |
Harmful effects or abnormalities |
Does not cause abnormalities |
Can cause abnormalities such as Down syndrome, cancer, or infertility |
Translocations, inversions and other chromosome rearrangements
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