| Basis Of Differentiation | Intracellular Enzymes | Extracellular Enzymes | 
| Definition | Are enzymes that are produced and retained inside the cell to be used within the cell itself | Are enzymes that are produced by the cell and released outside of the cell into the extracellular space for external use | 
| Also Known As | Endoenzymes | Exoenzymes | 
| Location | May be found unbound in the cytoplasmic fluid or bound to specific organelles such as ribosomes, mitochondria, or nucleus | Found in the extracellular fluid outside in tissue spaces, body fluids such as saliva and blood, or organ cavities such as intestine and stomach | 
| Activity | Function within the cell | Function outside the cell | 
| Functions | - Protein synthesis | |
| Mechanism of action | Break large polymer into small chains of monomer | Break lark polymer into small chain of monomer one at a time | 
| Type of digestion | Undergo intracellular digestion | Undergo extracellular digestion | 
| Involvement | Are responsible for the digestion of food particles inside the cytoplasm of unicellular organisms | Are responsible for the digestion of food inside the alimentary canal of higher animals and the extracellular digestion in decomposers such as bacteria and fungi | 
| Proportions | Account for the majority of enzymes | Account for the minority of enzymes | 
| Examples |