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AAT Bioquest

What are the common features of amyloids?

Posted July 11, 2024


Answer

Common features of amyloids include: 

  • Fibrillar appearance on electron micrography
  • X-ray diffraction pattern reveals beta-pleated sheet structure
  • Histological staining with Congo red results in apple-green birefringence 
  • Hematoxylin and eosin staining reveal amorphous eosinophilic appearance
  • Soluble in waters and buffers of low ionic strength 
Additional resources

Amyloid Structure: Conformational Diversity and Consequences

Neurodegeneration & Amyloid Staining

Congo Red *UltraPure grade* *CAS 573-58-0*