What are the applications for IgM antibodies?

IgM are large-sized antibodies capable of recognizing a large variety of pathogenic antigens and serve as key detection molecules in the immune system. This makes them a valuable asset in a wide range of common research applications including Flow Cytometry, ELISA, Western Blot, Immunofluorescence, Immunoprecipitation, Immunohistochemistry, and Immunocytochemistry/Immunofluorescence, among others. 

In addition to Antibody Drug Discovery assays, IgM antibodies also have several therapeutic applications. Their strong avidity and complement fixation ability make them an effective biologic against cancer. Their inherent ability to facilitate autoimmunity can be utilized to minimize graft rejections and improve the success rate of transplantation procedures. 

Researchers are exploring other applications for IgM antibodies including using them as a vaccine adjuvant, as a preventive vaccine, and in the treatment of arthritis.