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AAT Bioquest

What are postsynaptic potentials?

Posted July 3, 2024


Answer

Postsynaptic potentials (PSPs) are temporary changes in the electrical potential of a neuron. They occur when neurotransmitters released from presynaptic neurons attach to postsynaptic neurons, resulting in a change in the neuron’s electrical potential. The potential can be either excitatory or inhibitory. An excitatory potential excites the neuron, causing depolarization and potentially triggering an action potential. An inhibitory potential inhibits the neuron, resulting in hyperpolarization, which inhibits the postsynaptic neuron and reduces the likelihood of the neuron firing. 

Additional resources

Excitatory and Inhibitory Postsynaptic Potentials

Cell/Cytoplasmic Membrane Potential Activity & Analysis

Screen Quest™ Membrane Potential Assay Kit *Red Fluorescence*