How might entosis affect tumors?

Entosis can have both positive and negative effects on tumors. Entosis may act as a tumor-suppressor by destroying cancer cells. However, entosis can also lead to aneuploidy and polyploidy, which may promote tumor progression. Entosis may also create a competitive environment where cells compete for limited resources. In this case, cells that are known as engulfers with higher entosis capabilities have a higher survival advantage by eliminating the invading cells. This potentially promotes tumor growth. It has also been suggested entosis is a mechanism for immune evasion in tumors. Through internalization of immune cells, cancer cells may escape immune surveillance, and evade the immune system to promote tumor growth.