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AAT Bioquest

How does phagocytosis happen?

Posted August 14, 2024


Answer

Phagocytosis occurs in 4 main steps. 

  1. Recognition of the Target Particle: The cell identifies and binds to the particle that needs to be engulfed. This particle could be a pathogen, dead cell, or debris.
  2. Signaling to Activate the Internalization Machinery: After binding, intracellular signaling pathways are activated. This signaling involves various molecules and proteins that trigger changes in the cell’s cytoskeleton. 
  3. Phagosome Formation: The phagocyte's membrane engulfs the target particle, enclosing it within a newly formed vesicle called a phagosome. 
  4. Phagolysosome Maturation: This step involves the maturation of the phagosome into a phagolysosome. This process includes the fusion of the phagosome with lysosomes; the phagolysosome is then capable of breaking down and digesting the engulfed particle.
Additional resources

Phagocytosis: A Fundamental Process in Immunity

Plasma Membrane

Cell Meter™ Fluorimetric Phagocytosis Assay Kit *Red Fluorescence*