How do lyases and ligases differ in their roles in cellular metabolism?

Lyases participate in several different metabolic pathways including the tricarboxylic acid (TCA) cycle, contributing to the diversification of metabolic pathways. This makes it possible for cells to generate a wide range of biochemical intermediates, which are crucial for their functioning. 

Ligases play a pivotal role in ensuring accuracy during DNA replication, DNA repair, and the synthesis of RNA and proteins. This ensures that cellular and genetic integrity and functionality are maintained and contributes to the synthesis of various cellular macromolecules.