How are mRNA vaccines different from traditional vaccines?

Question

Accepted Answer

Some of the key differences between mRNA vaccines and traditional vaccines include the production flexibility, production time needed, how the immune system responds, and level of biosafety.

Basis of differentiation

mRNA vaccines

Traditional vaccines

Definition

Vaccines that work by teaching cells how to make a small, harmless piece of the virus to trigger an immune response inside the body

Vaccines that work by inserting a weakened or inactivated germ or virus into the body to trigger an immune response.

Manufacturing & development

Faster manufacturing time - mRNA vaccines can be quickly designed, tested, and mass produced

Slower manufacturing time - growing large amounts of infectious viruses and then inactivating them can take weeks, months, or even years

Shelf life

Up to 6 months

Varies by vaccine but may be 1-3 years

Flexibility

Production process can be easily standardized and scaled

Cannot be standardized or scaled – each new vaccine entails a tailored manufacturing process, including complex purification and testing

Effectiveness & safety

Effective and safe for the vast majority of people as they do not contain any whole microbes, alive or dead

Can be highly effective but are not safe for everyone as they contain a live virus, which has inherent risks

Length of immunity

Several booster shots may be required over time to maintain immunity

Varies from one vaccine to another - some may offer lifelong immunity while others may require booster shots at intervals

Basis of differentiation	mRNA vaccines	Traditional vaccines
Definition	Vaccines that work by teaching cells how to make a small, harmless piece of the virus to trigger an immune response inside the body	Vaccines that work by inserting a weakened or inactivated germ or virus into the body to trigger an immune response.
Manufacturing & development	Faster manufacturing time - mRNA vaccines can be quickly designed, tested, and mass produced	Slower manufacturing time - growing large amounts of infectious viruses and then inactivating them can take weeks, months, or even years
Shelf life	Up to 6 months	Varies by vaccine but may be 1-3 years
Flexibility	Production process can be easily standardized and scaled	Cannot be standardized or scaled – each new vaccine entails a tailored manufacturing process, including complex purification and testing
Effectiveness & safety	Effective and safe for the vast majority of people as they do not contain any whole microbes, alive or dead	Can be highly effective but are not safe for everyone as they contain a live virus, which has inherent risks
Length of immunity	Several booster shots may be required over time to maintain immunity	Varies from one vaccine to another - some may offer lifelong immunity while others may require booster shots at intervals

How are mRNA vaccines different from traditional vaccines?

Posted August 3, 2023