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AAT Bioquest

What's the difference between an early and late endosome?

Posted May 18, 2020


Answer

Early Endosomes:

  • The main sorting machine of the endocytic pathway
  • Relatively small
  • Often located in the periphery of the cytoplasm near the plasma membrane
  • Tubular and vacuolar in composition
  • Weakly acidic (pH 5.9-6.8)
  • Low Ca2+ concentration
  • Lack acid hydrolases

Late Endosomes:

  • May fuse with lysosomes to degrade cargo
  • Round or oval-shaped
  • Shuttle between peripheral cytoplasm and perinuclear area
  • Lumen often contains variously sized vesicles
  • More acidic than early endosomes (pH 4.9-6.0)
  • Increased Ca2+ concentration compared to early endosomes
  • Replete with acid hydrolases
Additional resources

Intracellular pH

ENDOCYTOSIS AND MOLECULAR SORTING