What's the difference between an early and late endosome?
Posted May 18, 2020
Answer
Early Endosomes:
- The main sorting machine of the endocytic pathway
- Relatively small
- Often located in the periphery of the cytoplasm near the plasma membrane
- Tubular and vacuolar in composition
- Weakly acidic (pH 5.9-6.8)
- Low Ca2+ concentration
- Lack acid hydrolases
Late Endosomes:
- May fuse with lysosomes to degrade cargo
- Round or oval-shaped
- Shuttle between peripheral cytoplasm and perinuclear area
- Lumen often contains variously sized vesicles
- More acidic than early endosomes (pH 4.9-6.0)
- Increased Ca2+ concentration compared to early endosomes
- Replete with acid hydrolases
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