What is the best DNA extraction method for genomics applications?

Phenol-chloroform DNA extraction is the most robust and widely used method, compared with all other methods. The basic principle of phenol-chloroform DNA extraction method is based on the liquid-liquid extraction of biomolecules. The protein portions of the cell are denatured and removed by separating DNA into the soluble phase. The entire mechanism of separation is based on the solubility of the biomolecules. This method yields high quality and high molecular weight DNA, which is required for genomic applications such as next generation sequencing, RFLP, etc. One of the disadvantages in this method is phenol contamination in the sample, which could be avoided by careful pipetting.