What does NAD+ do in the body?

NAD+ is the molecular link between cellular metabolism, signaling, and transcription. Its synthesis, availability, and degradation are therefore central to the function of the cell and in healthy human physiology, and have been a subject of interest to 3 Nobel laureates as well as countless research groups worldwide.

NAD+ levels and associated enzymes are essential for genomic maintenance. Since genomic stress and damage is the root source of all cancers, NAD+ regulation is of interest in fields that study cancer susceptibility and prevention.

There has been a huge amount of progress and discoveries made in recent years about the protein links between multiple cellular pathways and physiological conditions such as metabolic dysfunction and aging. Better methods of detection and visualization of NAD+ and associated biomolecules are pivotal in gaining further understanding of these interconnected aspects of human health and function.