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AAT Bioquest

Is BrdU (Bromodeoxyuridine) myelotoxic?

Posted September 3, 2021


Answer

No, BrdU (Bromodeoxyuridine) is not myelotoxic at labeling concentrations. This makes it a safe and effective tool for identifying and monitoring the proliferation of cancer cells in-vivo. However, BrdU’s use for radiosensitizing is limited because it becomes myelosuppressive at radiosensitizing concentrations.

Additional resources

Noninvasive measurement of hematopoietic stem cell cycling and turnover by in vivo bromodeoxyuridine incorporation

Cell Viability