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How does ATP activate the inflammasome?
Posted October 13, 2021
Physiological ProbesCell MetabolismCell Cycle AssaysCell Viability
Answer

In the event of a bacterial infection or sterile tissue injury, host immune cells release ATP (adenosine triphosphate) as an inflammatory signal. ATP then acts via a feedback mechanism on the P2X7 channel to induce NLRP3 inflammasome activation and subsequently process and release interleukin (IL)-18.

Additional resources
ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in MacrophagesPhosphoWorks™ Luminometric ATP Assay Kit *Extended Luminescence*

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