Do Ionic detergents denature proteins?

Yes, ionic detergents denature proteins. Ionic detergents bind strongly to protein molecules irreversibly breaking the protein’s intra- and intermolecular interactions and altering it conformation and function. This destroys the protein’s innate biological activity.

Ionic detergents are often used when the desired outcome involves disrupting cellular structures completely and denaturing proteins for separation for processes such as gel electrophoresis.