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Zinquin *CAS#: 151606-29-0*
Zinquin is a zinc-sensitive, cell-impermeable fluorescent probe. Zinc is the second most abundant transition metal in the body and it is essential as catalytic, structural and regulatory ion. Zinc ions are involved in homeostasis, immune responses, oxidative stress, apoptosis and aging. Zinc has been proposed to function as a conventional neurotransmitter for the presynaptic neuron and as a transmembrane signal to traverse the postsynaptic neuron. Aberrant zinc metabolism is associated with many neurological diseases including Alzheimer's disease, Parkinson's disease and epilepsy. The most suitable technique for in vivo monitoring of zinc has been proven to be fluorescence imaging.
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Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Zinquin *CAS#: 151606-29-0* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 258.786 µL | 1.294 mL | 2.588 mL | 12.939 mL | 25.879 mL |
| 5 mM | 51.757 µL | 258.786 µL | 517.572 µL | 2.588 mL | 5.176 mL |
| 10 mM | 25.879 µL | 129.393 µL | 258.786 µL | 1.294 mL | 2.588 mL |
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Citations
View all 1 citations: Citation Explorer
Biomimetic Nano-Immunoactivator via Ionic Metabolic Modulation for Strengthened NIR-II Photothermal Immunotherapy
Authors: Wei, Xiaodan and Huang, Honglin and Guo, Junhan and Li, Ningxi and Li, Qingzhi and Zhao, Tian and Yang, Geng and Cai, Lulu and Yang, Hong and Wu, Chunhui and others,
Journal: Small (2023): 2304370
Authors: Wei, Xiaodan and Huang, Honglin and Guo, Junhan and Li, Ningxi and Li, Qingzhi and Zhao, Tian and Yang, Geng and Cai, Lulu and Yang, Hong and Wu, Chunhui and others,
Journal: Small (2023): 2304370
References
View all 8 references: Citation Explorer
Zinquin identifies subcellular compartmentalization of zinc in cortical neurons. Relation to the trafficking of zinc and the mitochondrial compartment
Authors: Colvin RA, Laskowski M, Fontaine CP.
Journal: Brain Res (2006): 1
Authors: Colvin RA, Laskowski M, Fontaine CP.
Journal: Brain Res (2006): 1
S-Nitroso compounds interfere with zinc probing by Zinquin
Authors: Jansen S, Arning J, Dulcks T, Beyersmann D.
Journal: Anal Biochem (2004): 145
Authors: Jansen S, Arning J, Dulcks T, Beyersmann D.
Journal: Anal Biochem (2004): 145
Coordination and fluorescence of the intracellular Zn2+ probe [2-methyl-8-(4-toluenesulfonamido)-6-quinolyloxy]acetic acid (Zinquin A) in ternary Zn2+ complexes
Authors: Hendrickson KM, Geue JP, Wyness O, Lincoln SF, Ward AD.
Journal: J Am Chem Soc (2003): 3889
Authors: Hendrickson KM, Geue JP, Wyness O, Lincoln SF, Ward AD.
Journal: J Am Chem Soc (2003): 3889
Fluorescent detection of Zn(2+)-rich vesicles with Zinquin: mechanism of action in lipid environments
Authors: Snitsarev V, Budde T, Stricker TP, Cox JM, Krupa DJ, Geng L, Kay AR.
Journal: Biophys J (2001): 1538
Authors: Snitsarev V, Budde T, Stricker TP, Cox JM, Krupa DJ, Geng L, Kay AR.
Journal: Biophys J (2001): 1538
The synthesis and fluorescent properties of analogues of the zinc(II) specific fluorophore zinquin ester
Authors: Kimber MC, Mahadevan IB, Lincoln SF, Ward AD, Tiekink ER.
Journal: J Org Chem (2000): 8204
Authors: Kimber MC, Mahadevan IB, Lincoln SF, Ward AD, Tiekink ER.
Journal: J Org Chem (2000): 8204
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