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• Enhanced Aqueous Solubility – Improved hydrophilicity enables efficient labeling in aqueous environments with minimal organic solvents.
• High Quenching Efficiency – Optimized for superior energy transfer suppression, effectively quenching Tide Fluor™ 7 (TF7), Alexa Fluor 750, and Cy7.
• Optimized for Biological Assays – Increased solubility supports applications in biochemical and cellular environments with stringent aqueous conditions.
• Versatile Conjugation Chemistry – Enables efficient labeling of peptides and post-synthetic modification of amino-modified oligonucleotides.

The non-fluorescent Tide Quencher™ 7HWS Succinimidyl Ester (TQ7HWS Succinimidyl Ester) is a next-generation, highly water-soluble quencher optimized for fluorescence-based applications, particularly in oligonucleotide and peptide labeling. As an advanced derivative of TQ7WS, it features significantly enhanced water solubility, enabling efficient labeling in aqueous environments with minimal organic solvent requirements. Like TQ7WS, TQ7HWS is designed to be a superior quencher for fluorophores such as Tide Fluor™ 7 (TF7), Alexa Fluor 750, and Cy7, offering stronger absorption properties, higher quenching efficiency, and excellent solubility. The increased hydrophilicity of TQ7HWS acid further improves its applicability in biological and biochemical assays requiring stringent aqueous conditions. With its exceptional quenching performance, complete absence of background fluorescence, and excellent solubility, TQ7HWS provides a reliable and efficient solution for demanding fluorescence assays.

Tide Quencher™ 7HWS Succinimidyl Ester (TQ7HWS Succinimidyl Ester) selectively and efficiently reacts with primary amines, including lysine side chains in peptides and aminosilane-coated surfaces, under mildly basic conditions (pH 7–9). This reaction forms stable covalent amide bonds, making TQ7HWS Succinimidyl Ester a valuable reagent for peptide labeling. Additionally, it is utilized for the post-synthetic labeling of amino-modified oligonucleotides.