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TF2-HQKLVFFAK-TQ2 [TF2-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-TQ2]

TF2-HQKLVFFAK-TQ2 [TF2-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-TQ2] has much stronger fluoresce upon protease cleavage than the commonly used FRET peptide MCA-HQKLVFFA (K-DNP), a secretase FRET peptide substrate. In addition, the fluorescence of TF2 has much longer wavelength fluorescence than MCA, minimalizing the interference caused by the sample autofluorescence.

Spectrum

References

View all 50 references: Citation Explorer
Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells.
Authors: Houser, Mei C Q and Mitchell, Shane P C and Sinha, Priyanka and Lundin, Brianna and Berezovska, Oksana and Maesako, Masato
Journal: Sensors (Basel, Switzerland) (2023)
In-Depth Characterization of Endo-Lysosomal Aβ in Intact Neurons.
Authors: McKendell, Alec K and Houser, Mei C Q and Mitchell, Shane P C and Wolfe, Michael S and Berezovska, Oksana and Maesako, Masato
Journal: Biosensors (2022)
A novel synthetic derivative of biaryl guanidine as a potential BACE1 inhibitor, to treat Alzheimer's disease: In-silico, in-vitro and in-vivo evaluation.
Authors: Ali, Sayyad and Hassan Bin Asad, Muhammad Hassham and Javed, Muhammad Arslan and Javed, Tariq and Al-Kharaman, Yasser Msa and Latif, Muhammad and Mohsin, Sabeeh and Nawaz, Taufiq and Farid Hasan, Syed Muhammad and Iqbal, Jamshed and Babak, Borhan and Hussain, Izhar
Journal: Pakistan journal of pharmaceutical sciences (2022): 1339-1345
Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1.
Authors: Dai, Gucan
Journal: The Journal of general physiology (2022)
Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons.
Authors: Maesako, Masato and Houser, Mei C Q and Turchyna, Yuliia and Wolfe, Michael S and Berezovska, Oksana
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (2022): 145-154
Page updated on September 28, 2024

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Catalog Number13206
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Physical properties

Solvent

DMSO

Spectral properties

Extinction coefficient (cm -1 M -1)

80000

Excitation (nm)

500

Emission (nm)

522

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
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