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SMPEG4
SM(PEG)4 is an amine-to-sulfhydryl crosslinkers with 24.6 angstroms length. It has an amino group-reactive NHS ester and sulfhydryl group-reactive maleimide. The N-hydroxysuccinimide ester (NHS) group reacts specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds. The maleimide group reacts with reduced sulfhydryls at pH 6.5-7.5 to form stable thioether bonds. SM(PEG)4 is used for irreversibly crosslinking proteins or peptides by flexible PEG spacer arms. The PEG arms help maintain conjugate solubility, reducing tendency toward aggregation and immunogenicity. It is ideal for performing controlled, two-step protein conjugations as SMCC.
References
View all 50 references: Citation Explorer
Tertiary blends of PAMAM/PEG/PEG tissue bioadhesives.
Authors: Shah, Ankur Harish and Djordjevic, Ivan and Steele, Terry W J
Journal: Journal of the mechanical behavior of biomedical materials (2020): 103405
Authors: Shah, Ankur Harish and Djordjevic, Ivan and Steele, Terry W J
Journal: Journal of the mechanical behavior of biomedical materials (2020): 103405
Enhanced regeneration of osteochondral defects by using an aggrecanase-1 responsively degradable and N-cadherin mimetic peptide-conjugated hydrogel loaded with BMSCs.
Authors: Feng, Xue and Zhou, Tong and Xu, Peifang and Ye, Juan and Gou, Zhongru and Gao, Changyou
Journal: Biomaterials science (2020): 2212-2226
Authors: Feng, Xue and Zhou, Tong and Xu, Peifang and Ye, Juan and Gou, Zhongru and Gao, Changyou
Journal: Biomaterials science (2020): 2212-2226
Crosslinker length dictates step-growth hydrogel network formation dynamics and allows rapid on-chip photoencapsulation.
Authors: Jiang, Zhongliang and Shaha, Rajib and McBride, Ralph and Jiang, Kun and Tang, Mingchen and Xu, Bang and Goroncy, Alexander K and Frick, Carl and Oakey, John
Journal: Biofabrication (2020): 035006
Authors: Jiang, Zhongliang and Shaha, Rajib and McBride, Ralph and Jiang, Kun and Tang, Mingchen and Xu, Bang and Goroncy, Alexander K and Frick, Carl and Oakey, John
Journal: Biofabrication (2020): 035006
Cell encapsulation spatially alters crosslink density of poly(ethylene glycol) hydrogels formed from free-radical polymerizations.
Authors: Chu, Stanley and Maples, Mollie M and Bryant, Stephanie J
Journal: Acta biomaterialia (2020): 37-50
Authors: Chu, Stanley and Maples, Mollie M and Bryant, Stephanie J
Journal: Acta biomaterialia (2020): 37-50
A triply modified human adult hemoglobin with low oxygen affinity, rapid autoxidation and high tetramer stability.
Authors: Yan, Wenying and Shen, Lijuan and Yu, Weili and Wang, Ying and Wang, Quan and You, Guoxing and Zhao, Lian and Zhou, Hong and Hu, Tao
Journal: International journal of biological macromolecules (2020): 236-242
Authors: Yan, Wenying and Shen, Lijuan and Yu, Weili and Wang, Ying and Wang, Quan and You, Guoxing and Zhao, Lian and Zhou, Hong and Hu, Tao
Journal: International journal of biological macromolecules (2020): 236-242
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