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SMPEG2
SM(PEG)2 is an amine-to-sulfhydryl crosslinkers with 17.6 angstroms length. It has an amino group-reactive NHS ester and sulfhydryl group-reactive maleimide. The N-hydroxysuccinimide ester (NHS) group reacts specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds. The maleimide group reacts with reduced sulfhydryls at pH 6.5-7.5 to form stable thioether bonds. SM(PEG)2 is used for irreversibly crosslinking proteins or peptides by flexible PEG spacer arms. The PEG arms help maintain conjugate solubility, reducing tendency toward aggregation and immunogenicity. It is ideal for performing controlled, two-step protein conjugations as SMCC.
References
View all 49 references: Citation Explorer
Cross-linking of bovine rhodopsin with sulfosuccinimidyl 4-(N maleimidomethyl)cyclohexane-1-carboxylate affects its functionality.
Authors: Medina, Rafael and Perdomo, Deisy and Möller, Carolina and Bubis, José
Journal: The Biochemical journal (2020)
Authors: Medina, Rafael and Perdomo, Deisy and Möller, Carolina and Bubis, José
Journal: The Biochemical journal (2020)
Biocompatible Organic Coatings Based on Bisphosphonic Acid RGD-Derivatives for PEO-Modified Titanium Implants.
Authors: Parfenova, Lyudmila V and Lukina, Elena S and Galimshina, Zulfia R and Gil'fanova, Guzel U and Mukaeva, Veta R and Farrakhov, Ruzil G and Danilko, Ksenia V and Dyakonov, Grigory S and Parfenov, Evgeny V
Journal: Molecules (Basel, Switzerland) (2020)
Authors: Parfenova, Lyudmila V and Lukina, Elena S and Galimshina, Zulfia R and Gil'fanova, Guzel U and Mukaeva, Veta R and Farrakhov, Ruzil G and Danilko, Ksenia V and Dyakonov, Grigory S and Parfenov, Evgeny V
Journal: Molecules (Basel, Switzerland) (2020)
Dietary Pattern Specific Protein Biomarkers for Cardiovascular Disease: A Cross-Sectional Study in 2 Independent Cohorts.
Authors: Warensjö Lemming, Eva and Byberg, Liisa and Stattin, Karl and Ahmad, Shafqat and Lind, Lars and Elmståhl, Sölve and Larsson, Susanna C and Wolk, Alicja and Michaëlsson, Karl
Journal: Journal of the American Heart Association (2019): e011860
Authors: Warensjö Lemming, Eva and Byberg, Liisa and Stattin, Karl and Ahmad, Shafqat and Lind, Lars and Elmståhl, Sölve and Larsson, Susanna C and Wolk, Alicja and Michaëlsson, Karl
Journal: Journal of the American Heart Association (2019): e011860
Evaluation of the bioactivity about anti-sca-1/basic fibroblast growth factor-urinary bladder matrix scaffold for pelvic reconstruction.
Authors: Li, Jiankui and Chen, Xi and Ling, Kaijian and Liang, Zhiqing and Xu, Huicheng
Journal: Journal of biomaterials applications (2019): 808-818
Authors: Li, Jiankui and Chen, Xi and Ling, Kaijian and Liang, Zhiqing and Xu, Huicheng
Journal: Journal of biomaterials applications (2019): 808-818
Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts.
Authors: Stattin, Karl and Lind, Lars and Elmståhl, Sölve and Wolk, Alicja and Lemming, Eva Warensjö and Melhus, Håkan and Michaëlsson, Karl and Byberg, Liisa
Journal: European journal of preventive cardiology (2019): 1865-1873
Authors: Stattin, Karl and Lind, Lars and Elmståhl, Sölve and Wolk, Alicja and Lemming, Eva Warensjö and Melhus, Håkan and Michaëlsson, Karl and Byberg, Liisa
Journal: European journal of preventive cardiology (2019): 1865-1873
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