Salinomycin-HRP conjugate

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Physical properties

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Water

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

Overview SDS Protocol

Salinomycin is a polyether monocarboxylic acid produced by Streptomyces albus. It is used in the prevention of coccidiosis in poultry caused by E. necatrix, E. tenella, E. acervulina, E. brunette, E. maxima, and E. mivati. Salinomycin is active against certain Gram-positive bacteria, whereas Enterobacteriaceae are resistant. Salinomycin also has an inhibitory effect on Clostridium perfringens, thus the use of salinomycin leads to a decrease in the incidence of necrotic enteritis in broiler chickens. Salinomycin is considered as the marker residue and skin/fat as the target tissue. Salinomycin produces relatively low residue levels in the eggs compared with other polyether ionophores. Salinomycin-HRP conjugate is an essential reagent for quantifying Salinomycin by ELISA.

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Figure 1. Chemical structure for Salinomycin-HRP conjugate.

References

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Facile fabrication of a novel 3D rose like lanthanum doped zirconia decorated reduced graphene oxide nanosheets: An efficient electro-catalyst for electrochemical reduction of futuristic anti-cancer drug salinomycin during pharmacokinetic study [Biosens Bi
Authors: Alkahtani, Saad A and Mahmoud, Ashraf M and Mahnashi, Mater H and Ali, Ramadan and El-Wekil, Mohamed M
Journal: Biosensors & bioelectronics (2021): 113202

Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2 and MMP-9 via the AMPK/SIRT1 pathway in non-small cell lung cancer.
Authors: Hwang, Ki-Eun and Kim, Hyo-Jin and Song, In-Sol and Park, Chul and Jung, Jae Wan and Park, Do-Sim and Oh, Seon-Hee and Kim, Young-Suk and Kim, Hak-Ryul
Journal: International journal of medical sciences (2021): 715-726

Analysis of the Differences in the Expression of mRNAs and miRNAs Associated with Drug Resistance in Endometrial Cancer Cells Treated with Salinomycin.
Authors: Januszyk, Piotr and Januszyk, Krzysztof and Wierzbik-Strońska, Magdalena and Boroń, Dariusz and Grabarek, Beniamin
Journal: Current pharmaceutical biotechnology (2021): 541-548

Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer.
Authors: Talkowski, Karol and Kiełbasiński, Kamil and Peszek, Wojciech and Grabarek, Beniamin O and Boroń, Dariusz and Oplawski, Marcin
Journal: Current pharmaceutical biotechnology (2021): 317-326

Effects of Scrophularia striata hydroalcoholic extract in comparison to salinomycin on growth performance, intestinal health and immunity in broiler chickens following a mixed-species Eimeria challenge.
Authors: Rostami, Farhad and Taherpour, Kamran and Ghasemi, Hossein Ali and Akbari Gharaei, Mohammad and Shirzadi, Hassan
Journal: Veterinary parasitology (2021): 109417

Correction to: Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma.
Authors: Zhou, Jingfeng and Liu, Shenglan and Wang, Yun and Dai, Wei and Zou, Hailin and Wang, Shubo and Zhang, Jing and Pan, Jingxuan
Journal: Molecular cancer (2021): 47

Singly and doubly modified analogues of C20-epi-salinomycin: A new group of antiparasitic agents against Trypanosoma brucei.
Authors: Czerwonka, Dominika and Barcelos, Yzobelle and Steverding, Dietmar and Cioch, Aleksandra and Huczyński, Adam and Antoszczak, Michał
Journal: European journal of medicinal chemistry (2021): 112900

Ovarian activity and antioxidant indices during estrous cycle of Barki ewes under effect of thyme, celery and salinomycin as feed additives.
Authors: El-Zaher, Hussein M and Eid, Sherif Y and Shaaban, Mahmoud M and Ahmed-Farid, Omar A and Abd El Tawab, Ahmed M and Khattab, Mostafa S A
Journal: Zygote (Cambridge, England) (2021): 155-160

Lipid nanocapsules co-encapsulating paclitaxel and salinomycin for eradicating breast cancer and cancer stem cells.
Authors: Basu, Suparna Mercy and Yadava, Sunil Kumar and Singh, Ruby and Giri, Jyotsnendu
Journal: Colloids and surfaces. B, Biointerfaces (2021): 111775

Green one-pot synthesis of nitrogen and sulfur co-doped carbon quantum dots as new fluorescent nanosensors for determination of salinomycin and maduramicin in food samples.
Authors: Magdy, Galal and Abdel Hakiem, Ahmed F and Belal, Fathalla and Abdel-Megied, Ahmed M
Journal: Food chemistry (2021): 128539