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ReadiLeave™ Reversible Biotin Amine
ReadiLeave™ Reversible (RLR) Biotin is a newly developed biotin derivative that has significantly reduced affinity to avidin (including streptavidin) to make the binding of RLR biotin and streptavidin readily reversible when needed. It is complimentary to the regular biotin and has a moderate affinity to streptavidin to ensure a tight binding but not too tight to be reversed in contrast with the regular non-reversible biotin. ReadiLeave™ Reversible Biotin Amine is an excellent building block to develop reversible biotin probes and products for biological detections and purification using the well-known click reactions (CuAAC). It readily reacts with a carbonyl-containing biomolecule under various conditions. The affinity between streptavidin and biotin might be the strongest non-covalent interactions known in biological interactions. Streptavidin, a homotetrameric protein, exhibits an extraordinarily high affinity for biotin. Each streptavidin monomer can bind one biotin molecule, allowing a streptavidin protein to maximally bind four biotins. The streptavidin-biotin interaction is highly specific and remains robust under a wide range of conditions.
References
View all 50 references: Citation Explorer
Synthesis of highly fluorescent, amine-functionalized carbon dots from biotin-modified chitosan and silk-fibroin blend for target-specific delivery of antitumor agents.
Authors: Horo, Himali and Saha, Muktashree and Das, Himadree and Mandal, Bishnupada and Kundu, Lal Mohan
Journal: Carbohydrate polymers (2022): 118862
Authors: Horo, Himali and Saha, Muktashree and Das, Himadree and Mandal, Bishnupada and Kundu, Lal Mohan
Journal: Carbohydrate polymers (2022): 118862
Transfer hydrogenations catalyzed by streptavidin-hosted secondary amine organocatalysts.
Authors: Santi, Nicolò and Morrill, Louis C and Swiderek, Katarzyna and Moliner, Vicent and Luk, Louis Y P
Journal: Chemical communications (Cambridge, England) (2021): 1919-1922
Authors: Santi, Nicolò and Morrill, Louis C and Swiderek, Katarzyna and Moliner, Vicent and Luk, Louis Y P
Journal: Chemical communications (Cambridge, England) (2021): 1919-1922
A brand-new generation of fluorescent nano-neural tracers: biotinylated dextran amine conjugated carbonized polymer dots.
Authors: Liu, Yang and Liu, Junjun and Zhang, Jiayi and Li, Xiucun and Lin, Fangsiyu and Zhou, Nan and Yang, Bai and Lu, Laijin
Journal: Biomaterials science (2019): 1574-1583
Authors: Liu, Yang and Liu, Junjun and Zhang, Jiayi and Li, Xiucun and Lin, Fangsiyu and Zhou, Nan and Yang, Bai and Lu, Laijin
Journal: Biomaterials science (2019): 1574-1583
Improving the Application of High Molecular Weight Biotinylated Dextran Amine for Thalamocortical Projection Tracing in the Rat.
Authors: Xu, Dongsheng and Cui, Jingjing and Wang, Jia and Zhang, Zhiyun and She, Chen and Bai, Wanzhu
Journal: Journal of visualized experiments : JoVE (2018)
Authors: Xu, Dongsheng and Cui, Jingjing and Wang, Jia and Zhang, Zhiyun and She, Chen and Bai, Wanzhu
Journal: Journal of visualized experiments : JoVE (2018)
Amine Landscaping to Maximize Protein-Dye Fluorescence and Ultrastable Protein-Ligand Interaction.
Authors: Jacobsen, Michael T and Fairhead, Michael and Fogelstrand, Per and Howarth, Mark
Journal: Cell chemical biology (2017): 1040-1047.e4
Authors: Jacobsen, Michael T and Fairhead, Michael and Fogelstrand, Per and Howarth, Mark
Journal: Cell chemical biology (2017): 1040-1047.e4
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