Purified Mouse Anti-human Ep-CAM/Epithelial Specific Antigen Antibody *AHC0106, Monoclonal, IgG1, kappa*

Epithelial cell adhesion molecule is a transmembrane protein with a molecular weight of 35 kDa, expressed in the bicellular tight junction, apical plasma membrane and extracellular exosome of cells. It is sometimes referred to as cell surface glycoprotein trop-1, epithelial glycoprotein (Ep-CAM) and KS 1/4 antigen. In humans, epithelial cell adhesion molecule aids in organismal processes, for example, leukocyte migration, ureteric bud development and stem cell differentiation. Sequencing of epithelial cell adhesion molecule has exemplified it contains 3 conserved structural units: extracellular, cytoplasmic and thyroglobulin type-1 domain. Epithelial cell adhesion molecule aids in signal transduction involved in gene expression. It recognizes protein-containing complex and cadherin involved in cell-cell adhesion. It positively regulates cell motility, stem cell proliferation and cell population proliferation while also is involved in the negative regulation of cell-cell adhesion mediated by cadherin and apoptotic process. Mutations and abnormalities in epithelial cell adhesion molecule have been associated with a number of diseases, for instance, diarrhea 5 (DIAR5) and hereditary non-polyposis colorectal cancer 8 (HNPCC8). Diarrhea 5 with congenital tufting enteropathy, an autosomal recessive inheritancedisorder characterized by small for gestational age, Intractable diarrhea and villous atrophy, has especially been of interest to investigators.

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