Protonex™ Red 780 AM *Cell-Permeable*

Protonex™ Red 780 AM

Cell-Permeable

Protonex™ Red 780 AM is the cell-permeable version of Protonex™ Red 780. Protonex™ Red 780 dye works by changing its fluorescence intensity depending on the pH of the environment. Protonex™ Red 780 is minimally fluorescent at a basic pH and maximally fluorescent at an acidic pH. When Protonex™ Red 780 is bound to an acidic intracellular target, it becomes highly fluorescent and emits near-infrared light when excited by a red laser. By measuring the fluorescence intensity of Protonex™ Red 780, one can label or monitor the acidic intracellular targets in live cells.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
21186	1 mg	Price

References

View all 50 references: Citation Explorer

mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity.

Authors:

Sarker, Rafiquel and Tse, Chung Ming and Lin, Ruxian and McNamara, George and Singh, Varsha and Donowitz, Mark

Journal:

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology (2022): 39-49

Effects of Diluent pH on Enrichment and Performance of Dairy Goat X/Y Sperm.

Authors:

He, Qifu and Wu, Shenghui and Huang, Ming and Wang, Ying and Zhang, Kang and Kang, Jian and Zhang, Yong and Quan, Fusheng

Journal:

Frontiers in cell and developmental biology (2021): 747722

Intracellular pH regulation in mantle epithelial cells of the Pacific oyster, Crassostrea gigas.

Authors:

Ramesh, Kirti and Hu, Marian Y and Melzner, Frank and Bleich, Markus and Himmerkus, Nina

Journal:

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology (2020): 691-700

Altered Degranulation and pH of Neutrophil Phagosomes Impacts Antimicrobial Efficiency in Cystic Fibrosis.

Authors:

Hayes, Elaine and Murphy, Mark P and Pohl, Kerstin and Browne, Niall and McQuillan, Karen and Saw, Le Er and Foley, Clare and Gargoum, Fatma and McElvaney, Oliver J and Hawkins, Padraig and Gunaratnam, Cedric and McElvaney, Noel G and Reeves, Emer P

Journal:

Frontiers in immunology (2020): 600033

Importance of measuring endolysosome, cytosolic, and extracellular pH in understanding the pathogenesis of and possible treatments for glioblastoma multiforme.

Authors:

Halcrow, Peter and Khan, Nabab and Datta, Gaurav and Ohm, Joyce E and Chen, Xuesong and Geiger, Jonathan D

Journal:

Cancer reports (2019)

Physical properties

Molecular weight	798.89
Solvent	DMSO

Spectral properties

Excitation (nm)	748
Emission (nm)	769

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12352200

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

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Page updated on October 25, 2025