Protonex™ Lyso-NIR 770
Protonex™ Lyso-NIR 770 is a fluorescent derivative prepared from our Protonex™ NIR 770 NHS ester. It is cell-permeable and selectively localized in acidic organelles such as lysosomes. It is the only cell-permeable acidotropic pH dye with NIR fluorescence for monitoring pH changes in acidic organelles. Its fluorescence can be readily captured with the common Cy7 filter set that is equipped with most of the fluorescence instruments. Due to its significantly red-shifted excitation and emission wavelengths, it has much lower background than the existing pH sensors (such as Lysosensors). It might be used in vivo for monitoring pH changes in animals due to the significantly improved skin-penetration capability of NIR excitation.
Spectrum
References
View all 50 references: Citation Explorer
Rational design of a ratiometric fluorescent probe for imaging lysosomal nitroreductase activity.
Authors: Bai, Wenjun and Li, Yixuan and Zhao, Li and Li, Ruxin and Geng, Jiahou and Lu, Yang and Zhao, Yufen and Wang, Jinhui
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2023): 123032
Authors: Bai, Wenjun and Li, Yixuan and Zhao, Li and Li, Ruxin and Geng, Jiahou and Lu, Yang and Zhao, Yufen and Wang, Jinhui
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (2023): 123032
A potent fluorescent transmembrane HCl transporter perturbs cellular pH and promotes cancer cell death.
Authors: Fares, Mohamed and Wu, Xin and McNaughton, Daniel A and Gilchrist, Alexander M and Lewis, William and Keller, Paul A and Arias-Betancur, Alain and Fontova, Pere and Pérez-Tomás, Ricardo and Gale, Philip A
Journal: Organic & biomolecular chemistry (2023): 2509-2515
Authors: Fares, Mohamed and Wu, Xin and McNaughton, Daniel A and Gilchrist, Alexander M and Lewis, William and Keller, Paul A and Arias-Betancur, Alain and Fontova, Pere and Pérez-Tomás, Ricardo and Gale, Philip A
Journal: Organic & biomolecular chemistry (2023): 2509-2515
Analysis of Radachlorin localization in living cells by fluorescence lifetime imaging microscopy.
Authors: Belashov, A V and Zhikhoreva, A A and Salova, A V and Belyaeva, T N and Litvinov, I K and Kornilova, E S and Semenova, I V and Vasyutinskii, O S
Journal: Journal of photochemistry and photobiology. B, Biology (2023): 112699
Authors: Belashov, A V and Zhikhoreva, A A and Salova, A V and Belyaeva, T N and Litvinov, I K and Kornilova, E S and Semenova, I V and Vasyutinskii, O S
Journal: Journal of photochemistry and photobiology. B, Biology (2023): 112699
In vivo Assessment of Lysosomal Stress in the Drosophila Brain Using Confocal Fluorescence Microscopy.
Authors: Martelli, Felipe
Journal: Bio-protocol (2023): e4599
Authors: Martelli, Felipe
Journal: Bio-protocol (2023): e4599
A water-soluble fluorescent pH probe and its application for monitoring lysosomal pH changes in living cells.
Authors: Zhang, Lei and Guo, Jun and You, Qihua and Xu, Yuqing
Journal: Analytical methods : advancing methods and applications (2023): 3057-3063
Authors: Zhang, Lei and Guo, Jun and You, Qihua and Xu, Yuqing
Journal: Analytical methods : advancing methods and applications (2023): 3057-3063
Page created on January 15, 2024, last updated on September 1, 2024