PE Mouse Anti-human/mouse FoxP3 Antibody *3G3, monoclonal*

Forkhead box protein P3 is a 47 kDa protein that can be found in the nuclear chromatin, cytoplasm and nucleoplasm of cells. In Homo sapiens, forkhead box protein P3 is the subject of intensive application due to the fact that it is a component of the T cell receptor signaling pathway and regulation of Wnt signaling pathway. Forkhead box protein P3 is a promoter of peripheral T cell tolerance induction, histone acetylation and DNA-templated transcription, on the other hand, also negatively regulates interleukin-17 production, interleukin-4 production and activated T cell proliferation. It is an integral part of DNA-templated transcription, isotype switching to IgG isotypes and T cell anergy, and also, binds to Fork-head and sequence-specific DNA. Forkhead box protein P3 has been associated with key functions like protein homodimerization, DNA-binding transcription factor and transcription corepressor activity, and furthermore, plays an important role in organismal processes, for instance, T cell mediated immunity, T cell activation and response to virus. Forkhead box protein P3 is clinically significant because abnormalities in its function have been thought to be involved with diseases such as Immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX). Immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome- , a x-linked recessive inheritancedisorder characterized by Diabetes mellitus, Immune dysregulation and Eosinophilia- has especially been of interest to researchers.

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