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OG488 Taxol Conjugate
OG488 Taxol Conjugate is the same compound as Oregon Green® 488 paclitaxel (also known as Flutax-2). Taxol, also known as Paclitaxel, is an anticancer agent. Taxol is known to promote tubulin assembly into stable aggregated structures. The green fluorescent OG488 Taxol Conjugate is an effective fluorescent probe for studying microtubules in cells and in solutions. The fluorescent label OG488 is attached to paclitaxel by derivatization of the 7-β-hydroxy group of native paclitaxel, minimizing the interference of OG488 fluorophore on the binding of the probe to microtubules. OG488 Taxol Conjugate has been successfully used for live-cell tubulin labeling. The binding of OG488 Taxol Conjugate to microtubules can be conveniently analyzed either by FACS or fluorescence imaging.
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References
View all 5 references: Citation Explorer
Paclitaxel-loaded expansile nanoparticles enhance chemotherapeutic drug delivery in mesothelioma 3-dimensional multicellular spheroids.
Authors: Lei, Hongyi and Hofferberth, Sophie C and Liu, Rong and Colby, Aaron and Tevis, Kristie M and Catalano, Paul and Grinstaff, Mark W and Colson, Yolonda L
Journal: The Journal of thoracic and cardiovascular surgery (2015): 1417-24; discussion 1424-25.e1
Authors: Lei, Hongyi and Hofferberth, Sophie C and Liu, Rong and Colby, Aaron and Tevis, Kristie M and Catalano, Paul and Grinstaff, Mark W and Colson, Yolonda L
Journal: The Journal of thoracic and cardiovascular surgery (2015): 1417-24; discussion 1424-25.e1
Killed Bacillus subtilis spores expressing streptavidin: a novel carrier of drugs to target cancer cells.
Authors: Nguyen, Van Anh Thi and Huynh, Hong Anh and Hoang, Tong Van and Ninh, Ngoc Thi and Pham, An Thi Hong and Nguyen, Hoa Anh and Phan, Tuan-Nghia and Cutting, Simon M
Journal: Journal of drug targeting (2013): 528-41
Authors: Nguyen, Van Anh Thi and Huynh, Hong Anh and Hoang, Tong Van and Ninh, Ngoc Thi and Pham, An Thi Hong and Nguyen, Hoa Anh and Phan, Tuan-Nghia and Cutting, Simon M
Journal: Journal of drug targeting (2013): 528-41
Biodegradable polymersomes as carriers and release systems for paclitaxel using Oregon Green® 488 labeled paclitaxel as a model compound.
Authors: Lee, Jung Seok and Feijen, Jan
Journal: Journal of controlled release : official journal of the Controlled Release Society (2012): 312-8
Authors: Lee, Jung Seok and Feijen, Jan
Journal: Journal of controlled release : official journal of the Controlled Release Society (2012): 312-8
Drug resistance to paclitaxel is not only associated with ABCB1 mRNA expression but also with drug accumulation in intracellular compartments in human lung cancer cell lines.
Authors: Shimomura, Masanori and Yaoi, Takeshi and Itoh, Kyoko and Kato, Daishiro and Terauchi, Kunihiko and Shimada, Junichi and Fushiki, Shinji
Journal: International journal of oncology (2012): 995-1004
Authors: Shimomura, Masanori and Yaoi, Takeshi and Itoh, Kyoko and Kato, Daishiro and Terauchi, Kunihiko and Shimada, Junichi and Fushiki, Shinji
Journal: International journal of oncology (2012): 995-1004
Direct assessment of P-glycoprotein efflux to determine tumor response to chemotherapy.
Authors: Patwardhan, Gauri and Gupta, Vineet and Huang, Juowen and Gu, Xin and Liu, Yong-Yu
Journal: Biochemical pharmacology (2010): 72-9
Authors: Patwardhan, Gauri and Gupta, Vineet and Huang, Juowen and Gu, Xin and Liu, Yong-Yu
Journal: Biochemical pharmacology (2010): 72-9
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